C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 38/57 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/14 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 41/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C07K 16/38
Patent
CA 2398775
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention concerne des compositions et procédés de stimulation ou d'inhibition de l'angiogenèse et/ou de la cardiovascularisation, chez des mammifères, et notamment chez l'homme. Des compositions pharmaceutiques, à base de polypeptides ou d'antagonistes de ces polypeptides, ont été identifiées qui conviennent à l'une, au moins, de ces utilisations. Des troubles diagnostiqués, prévenus ou traités au moyens de ces compositions, comprennent des traumas, tels que des plaies, divers cancers, et des pathologies des vaisseaux, notamment l'athérosclérose et l'hypertrophie cardiaque. En outre, l'invention concerne des nouveaux polypeptides ainsi que des molécules d'acides nucléiques codant pour ces polypeptides, de même que des vecteurs et cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules de polypeptides chimères comprenant les polypeptides de l'invention fusionnés à des séquences de polypeptides hétérologues, des anticorps se liant aux polypeptides de l'invention, ainsi que des procédés de production de ces polypeptides.
Gurney Austin L.
Kirchhofer Daniel K.
Wood William I.
Genentech Inc.
Smart & Biggar
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