C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/14 (2006.01) A61K 31/535 (2006.01) C07D 295/092 (2006.01) C07D 295/155 (2006.01) C12N 1/20 (2006.01)
Patent
CA 2052874
60/RDM31 18166 TITLE OF THE INVENTION INHIBITOR OF HIV PROTEASE ABSTRACT OF THE DISCLOSURE A novel dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Arison Byron H.
Colwell Lawrence F. Jr.
Dezeny Georgette
Kohl Nancy E.
Lingham Russell B.
Arison Byron H.
Colwell Lawrence F. Jr.
Dezeny Georgette
Goudreau Gage Dubuc
Kohl Nancy E.
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