C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/35 (2006.01) A61K 35/18 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2071896
2071896 9204049 PCTABS00011 Peptides having at least seven amino acids, preferably up to 20 amino acids, and most preferably 7 to 9 amino acids, comprising an amino acid sequence which corresponds to positions 180-186 of the Mycobacterium tuberculosis protein hsp 65 having the formula TFGLQLE, but differing therefrom by one to three amino acid substitutions in the positions 181-183, are disclosed. These peptides inhibit antigen recognition by T lymphocytes, such as recognition of hsp 65, and are capable of protecting a subject from an immune-related disease, such as autoimmune arthritis and to prevent rejection of a transplanted organ or tissue. Single amino acid substitutions, in particular with alanine, at positions corresponding to hsp 65 positions 183 and 181 are preferred. T cell lines specific for the above peptides and their use in treating or preventing immune-related disease is also disclosed.
Boog Claire J. P.
Cohen Irun R.
Van Der Zee Ruurd
Van Eden Willem
Wauben Marca H. M.
de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van W Volksgezondheid En Cultuur
Gowling Lafleur Henderson Llp
Rijksuniversiteit Te Utrecht
Yeda Research And Development Co. Ltd.
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