Inhibitor of pai-1 production

Details Inhibitor of pai-1 production Inhibitor of pai-1 production

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 31/5375 (2006.01) A61P 7/02 (2006.01) A61P 43/00 (2006.01) C07D 295/20 (2006.01)

Patent

CA 2703494

The compound represented by the following general formula (I) has an inhibitory activity on PAI-1 production; [Formula 1] (see formula I) wherein: R1 represents, for example, a hydrogen atom, or a 4- (morpholinyl)carbonyl group, ring D represents, for example, a benzene ring or a benzene ring having substituent(s), and phenyl group E has substituent(s) such as a halogen atom, a halogenated alkyl group, an alkyl group, a halogenated alkoxy group, or an alkoxy group.

L'invention porte sur un composé représenté par la formule générale (I) ci-après, qui présente une activité inhibitrice de la production de PAI-1. (I) (Dans la formule, R1 représente, par exemple, un atome d'hydrogène ou un groupe 4-(morpholinyl)carbonyle ; le noyau D représente, par exemple, un noyau benzène ou un noyau benzène substitué ; le groupe phényle E possède un substituant tel qu'un atome d'halogène, un groupe alkyle halogéné, un groupe alkyle, un groupe alcoxy halogéné ou un groupe alcoxy).

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