Inhibitor of visual function disturbance caused by optic...

A - Human Necessities – 61 – K

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A61K 31/496 (2006.01) A61P 27/02 (2006.01) C07D 211/90 (2006.01)

Patent

CA 2369299

Inhibitors for optic hypofunction caused by optic nerve cell injury induced by factors other than optic circulatory disorder which contain as the active ingredient 1,4-dihydropyridine derivatives represented general formula (I) or acid addition salts thereof: wherein X1 and X2 are the same or different and each represents hydrogen, fluoromethyl, fluoromethoxy, halogeno, cyano or nitro; R1 represents lower alkyl; R2 represents acyl, alkoxycarbonyl, acylalkyl, N-alkylated carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-alkyl, haloalkyl, alkenyl or alkynyl; A represents alkylene having at least five carbon atoms in total and having carbon to which two alkyl groups are attached; and m is an integer of from 1 to 3.

L'invention concerne des inhibiteurs d'hypofonction optique provoquée par une lésion d'une cellule du nerf optique induite par des facteurs autres que les troubles circulatoires optiques comprenant des dérivés de 1,4-dihydropyridine comme principe actif de formule générale (I) ou leurs sels d'addition acide. Dans la formule (I), X1 et X2 sont identiques ou différentes et représentent chacun un hydrogène, fluorométhyle, fluorométhoxy, halogeno, cyano ou nitro ; R1 représente un alkyle inférieur; R2 représente un acyle, alcoxycarbonyle, acylalkyle, carbamoylalkyl N-alkylé, alcoxyalkyle, alcoxycarbonylalkyle, acyloxyalkyle, nitratoalkyle, cyanoalkyle, hétérocycle-alkyle, haloalkyle, alcényle ou alkynyle; A représente un alkylène ayant au moins cinq atomes de carbone au total dont un carbone est lié à deux groupes alkyle et m représente un entier compris entre 1 et 3.

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