Inhibitor-resistant hcv ns3 protease

Details Inhibitor-resistant hcv ns3 protease Inhibitor-resistant hcv ns3 protease

C - Chemistry, Metallurgy

12

N

C12N 9/50 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2498653

An inhibitor-resistant HCV NS3 protease is provided which is useful to screen for compounds having therapeutic value against drug resistant HCV strains. In particular, the inhibitor-resistant HCV NS3 protease comprises an amino acid sequence which is mutated in the substrate binding pocket thereof rendering the protease resistant to inhibitor. In a specific aspect of the present invention, at least one of the amino acids at position 155, 156 and 168 of the HCV NS3 protease is mutated to yield an inhibitor-resistant protease.

L'invention concerne la protéase NS3 du VHC résistante aux inhibiteurs qui sert à cribler des composés présentant une valeur thérapeutique contre des souches du VHC résistantes aux médicaments. En particulier, la protéase NS3 du VHC résistante aux inhibiteurs comprend une séquence d'acides aminés qui est mutée dans la poche de liaison au substrat de celle-ci, rendant la protéase résistante aux inhibiteurs. Dans un aspect spécifique de l'invention, au moins un des acides aminés en position 155, 156 et 168 de la protéase NS3 du VHC est muté afin d'obtenir une protéase résistante aux inhibiteurs.

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