Inhibitor screening method and atopic dermatitis-like...

Details Inhibitor screening method and atopic dermatitis-like... Inhibitor screening method and atopic dermatitis-like...

G - Physics

01

N

G01N 33/50 (2006.01) C12N 1/02 (2006.01) C12Q 1/00 (2006.01) G01N 33/15 (2006.01)

Patent

CA 2523297

The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocytes (KC), and their usages. The methods are preferably applicable for the understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying on the skin of mice or the like, protein A (SpA), derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to a high level in serum, and this elevation is normally generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.

L'invention concerne diverses méthodes pouvant être utilisées de manière appropriée dans l'étude du mécanisme d'apparition des symptômes de la dermatite atopique (AD) et des symptômes similaires, et un remède associé, dans lesquels on utilise le phénomène d'induction de la production de l'interleukine 18 (IL-18) par les kératinocytes (KC), et leurs méthodes d'utilisation. L'expression d'IgE à un niveau élevé dans le sérum, observée dans une lésion du type AD, peut être reproduite, par exemple par l'application de la protéine A provenant de staphylococcus aureus (SpA) sur la peau d'une souris ou similaire, ou par la transplantation d'une partie de peau présentant une lésion inflammatoire du type AD sur une souris ou similaire. Il devient ainsi possible de cribler, par exemple, un inhibiteur de l'induction de la production d'IL-18 par les KC.

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