Inhibitor screening method and atopic dermatitis-like...

Details Inhibitor screening method and atopic dermatitis-like... Inhibitor screening method and atopic dermatitis-like...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01)

Patent

CA 2690035

The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocytes (KC), and their usages. The methods are preferably applicable for the understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying on the skin of mice or the like, protein A (SpA), derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to a high level in serum, and this elevation is normally generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.

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