Inhibitors against the activation of ap-1 and nfat

Details Inhibitors against the activation of ap-1 and nfat Inhibitors against the activation of ap-1 and nfat

A - Human Necessities

61

K

A61K 31/055 (2006.01) A61K 31/00 (2006.01) A61K 31/121 (2006.01) A61K 31/15 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61K 31/185 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/222 (2006.01) A61K 31/275 (2006.01) A61K 31/357 (2006.01) A61K 31/381 (2006.01) A61K 31/402 (2006.01) A61K 31/403 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/4164 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/433 (2006.01) A61K 31/

Patent

CA 2487891

Medicines for inhibiting the activation of AP-1, containing as the active ingredient substances selected from the group consisting of compounds represented by the general formula (I) and pharmacologically acceptable salts thereof, and hydrates and solvates of both: (I) wherein X is a connecting group whose main chain has 2 to 5 carbon atoms and which may have a substituent; A is hydrogen or acetyl; E is optionally substituted aryl or optionally substituted heteroaryl; and Z is arene which may have a substituent in addition to the groups represented by the general formulae: -O-A and -X-E, or heteroarene which may have a substituent in addition to the groups represented by the general formulae: -O-A and -X-E.

L'invention concerne des médicaments servant à inhiber l'activation d'AP-1, qui contiennent comme principe actif des matières sélectionnées dans le groupe constitué par les composés représentés par la formule générale (I), les sels pharmacologiquement acceptables de ces composés, ainsi que leurs hydrates et solvates. Dans la formule, X est un groupe de liaison dont la chaîne principale comporte de 2 à 5 atomes de carbone, et qui peut présenter un substituant ; A représente hydrogène ou acétyle ; E est aryle éventuellement substitué ou hétéroaryle éventuellement substitué ; et Z représente arène pouvant comporter un substituant en plus des groupes représentés par les formules -O-A et X-E, ou hétéroarène pouvant comporter un substituant en plus des groupes représentés par les formules générales -O-A et X-E.

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