Inhibitors for use in hemostasis

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2478675

The present invention relates to peptide, polynucleotide and fusion proteins for use as inhibitors in hemostasis. These inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacify collagenous surfaces and modulating wound healing.

La présente invention concerne un peptide, un polynucléotide et des protéines de fusion convenant particulièrement comme inhibiteurs pour l'hémostase. Ces inhibiteurs appartiennent à une famille de protéines portant un domaine ressemblant au collagène et un domaine globulaire. Ces inhibiteurs conviennent particulièrement pour favoriser l'écoulement du sang dans le système vasculaire, par réduction de l'activité de thrombogenèse et de complémentation. Ces inhibiteurs conviennent également particulièrement à la pacification des surfaces collagéniques et à la modulation de la guérison des blessures.

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