Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1...

Details Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1... Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/4709 (2006.01) A61P 3/04 (2006.01) A61P 9/12 (2006.01) A61P 19/02 (2006.01) A61P 27/06 (2006.01) C07C 209/42 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 235/08 (2006.01) C07D 235/30 (2006.01) C07D 263/56 (2006.01) C07D 277/62 (2006.01) C07D 277/64 (2006.01) C07D 277/68 (2006.01) C07D 277/74 (2006.01) C07D 277/82 (2006.01) C12Q 1/32 (2006.01)

Patent

CA 2501228

There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.

L'invention concerne un composé de formule (I). Dans cette formule R¿1? et R¿2? désignent un groupe de formule (a). Dans cette formule R¿4? est sélectionné parmi H et hydrocarbyle, R¿5? désigne un groupe hydrocarbyle et L désigne un groupe de liaison optionnel, ou R¿1? et R¿2? forment ensemble un anneau substitué avec le groupe (a), R¿3? désignant H ou un substituant, et X étant sélectionné dans S, O, NR¿6? et C(R¿7?)(R¿8?), R¿6? étant sélectionné parmi H et des groupes hydrocarbyle, R¿7? et R¿8? étant indépendamment sélectionnés parmi H et des groupes hydrocarbyle.

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