Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Details Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

C - Chemistry, Metallurgy

07

D

C07D 277/60 (2006.01) A61K 31/426 (2006.01) A61P 3/00 (2006.01) A61P 5/48 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 31/06 (2006.01) A61P 31/12 (2006.01) C07D 277/52 (2006.01) C07D 277/56 (2006.01) C07D 277/84 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/08 (2006.01) C07D 513/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2408144

The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, - CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is H, C1-6-alkyl, C1-6- acyl or -COR4; R4 is morpholino or C1-6-amido; R6 and R7 are independently hydrogen or C1-6-alkyl; and R8 and R9 are independently hydrogen or C1-6- alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.

La présente invention concerne un composé de la formule (I) où T représente I) thiényle éventuellement substitué par un halogène, ou II) phényle éventuellement substitué par un halogène et/ou C¿1-6?-alkyle; E représente un lien, -CH¿2?- ou -CO-; L représente un lien, -CH¿2?-, -CHR?4¿- ou -NR?3¿-; R?3¿ représente H, C¿1-6?-alkyle, C¿1-6?-acyle ou -COR?4¿; R?4¿ représente morpholino ou C¿1-6?-amido; R?6¿ et R?7¿ représentent indépendamment hydrogène ou C¿1-6?-alkyle; et R?8¿ et R?9¿ représentent indépendamment hydrogène ou C¿1-6?-alkyle, ainsi que des sels pharmaceutiquement acceptables, leurs hydrates et leurs solvates. Ce composé est utilisé dans la production d'un médicament pour le traitement ou la prévention de diabètes, du syndrome X, de l'obésité, d'un glaucome, de l'hyperlipidémie, de l'hyperglycémie, del'hyperinsulinémie, de l'ostéoporose, de la tuberculose, de la démence, de la dépression, de maladies virales et de troubles inflammatoires.

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