Inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/107 (2006.01) A61K 31/407 (2006.01)

Patent

CA 2587153

The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-.beta. hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

La présente invention concerne des inhibiteurs de la 11-.beta.-hydroxystéroïde déhydrogénase de type 1, des antagonistes du récepteur minéralocorticoïde (MR) et des compositions pharmaceutiques les comprenant. Les composés de l~invention peuvent être utiles dans le traitement de diverses pathologies associées à l~expression ou à l~activité de la 11-.beta.-hydroxystéroïde déhydrogénase de type 1 et/ou de pathologies accompagnées d~un excès d~aldostérone.

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