Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

C - Chemistry – Metallurgy – 07 – D

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C07D 207/27 (2006.01) A61K 31/4015 (2006.01) A61P 3/00 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2649111

The present invention discloses novel compounds of Formula I: having 11.beta. -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11.beta.-HSD type 1 activity.

La présente invention a pour objet de nouveaux composés de Formule I : d'activité antagoniste vis-à-vis de la 11.beta.-HSD de type 1, ainsi que des méthodes de synthèse de tels composés. Dans un autre mode d'application, la présente invention concerne des compositions pharmaceutiques comprenant des composés de Formule I, ainsi que des méthodes d'utilisation des composés et des compositions dans le traitement du diabète, de l'hyperglycémie, de l'obésité, de l'hypertension, de l'hyperlipidémie, du syndrome métabolique et d'autres états pathologiques associés à l'activité de la 11.beta.-HSD de type 1.

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