C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2126203
2126203 9313124 PCTABS00024 The present invention relates to certain substituted 17.beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) wherein R1 and R1 are: i) independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R1 and R2 is a single bond; R3c is hydrogen; R4c is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, alkanoyl of 2-6 carbons, -(CH2)mCO2R16, -(CH2)mAra, -(CH2)n'CONR17R18, -(CH2)n'NR17R18 or -(CH2)n'OR16, wherein R16 is hydrogen, lower alkyl or lower alkenyl; R17 and R18 are independly hydrogen, lower alkyl lower cycloalkyl or lower alkenyl; Ara is an aromatic group of 6 to 12 carbons; n' is 0 or an integer from 1 to 5; m is an integer from 1 to 5; R19 and R20 are independently hydrogen or lower alkyl, or taken together R19 and R20 form a carbonyl group(=O); R5c is lower alkyl, lower alkenyl, lower cycloalkyl, lower alkoxy, or NR21R22, wherein R21 and R22 are independently hydrogen, lower alkyl or lower alkenyl; and pharmaceutically acceptable salts thereof, their preparation, medical use and pharmaceutical formulations.
Andrews Robert C.
Cribbs Cynthia M.
Frye Stephen V.
Haffner Curt D.
Maloney Patrick R.
Glaxo Inc.
Riches Mckenzie & Herbert Llp
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