A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 31/135 (2006.01) A61K 31/445 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2427330
The present invention relates to inhibitors of drug transporters of the ABC protein superfamily, particularly transporters present at the blood brain barrier. ABC transporter inhibitors identified according to the invention increase brain concentrations of CNS-active agents. Such inhibitors increase the influx into the brain and/or reduce the efflux from the brain of such CNS- active agents.
L'invention concerne des inhibiteurs de transporteurs du médicament de la superfamille des protéines ABC, plus spécifiquement de transporteurs présents au niveau de la barrière hémato-encéphalique. Les inhibiteurs de transporteurs d'ABC identifiés selon cette invention augmentent les concentrations dans le cerveau d'agents actifs au niveau du SNC. De tels inhibiteurs augmentent l'afflux au cerveau et/ou diminue le flux sortant à partir du cerveau de tels agents actifs au niveau du SNC.
Pain Therapeutics Inc.
Ridout & Maybee Llp
LandOfFree
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