Inhibitors of adp-ribosyl transferases, cyclases, and...

C - Chemistry – Metallurgy – 07 – H

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Details

C07H 19/048 (2006.01) A61K 31/70 (2006.01) C07H 19/04 (2006.01) C07H 19/052 (2006.01)

Patent

CA 2487566

The present invention provides compounds having the formula: (I); Also provided are pro-drug compounds of the formula: (II); The invention also provides pharmaceutical compositions containing the above compounds, methods of using the above compounds as pharmaceuticals, and processes for preparing the above compounds. Methods for inhibiting an ADP-ribosyl transferase, ADP- ribosyl cyclase, ADP-ribosyl hydrolase, or NAD-dependent deacetylase enzyme using the above compounds, and methods for treating a disease or condition associated with an ADP-ribosyl transferase, ADP- 'ribosyl cyclase, ADP-ribosyl hydrolase, or NAD-dependent deacetylase enzyme in a subject using the above compounds are also provided.

L'invention concerne des composés représentés par la formule (I), ainsi que des composés de promédicaments représentés par la formule (II). De plus, l'invention concerne des compositions pharmaceutiques contenant les composés susmentionnés, des procédés d'utilisation de ces composés en tant que produits pharmaceutiques ainsi que des procédés de préparation des composés susmentionnés. Enfin, l'invention concerne également des procédés permettant d'inhiber une ADP-ribosyl transférase, ADP-ribosyl cyclase, ADP-ribosyl hydrolase, ou une enzyme déacétylase dépendante de NAD à l'aide des composés susmentionnés, ainsi que des procédés permettant de traiter une maladie ou un état pathologique associés à une ADP-ribosyl transférase, ADP-ribosyl cyclase, ADP-ribosyl hydrolase, ou à une enzyme déacétylase dépendante de NAD chez un sujet, à l'aide des composés susmentionnés.

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