Inhibitors of akt activity

A - Human Necessities – 61 – K

Patent

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A61K 31/395 (2006.01)

Patent

CA 2576172

The present invention is directed to compounds which contain substituted 5- deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

La présente invention concerne des composés contenant des fractions 5-désazaptéridine substituées qui inhibent l'activité de Akt, une protéine kinase sérine/thréonine. L'invention concerne également des compositions chimiothérapeutiques contenant les composés susmentionnés ainsi que des méthodes destinées à traiter le cancer et consistant à administrer lesdits composés.

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