Inhibitors of akt activity

Details Inhibitors of akt activity Inhibitors of akt activity

C - Chemistry, Metallurgy

07

D

C07D 241/36 (2006.01) A61K 31/495 (2006.01) A61K 45/06 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2501365

The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

L'invention concerne des composés qui contiennent un noyau hétérocyclique à cinq éléments réunis par fusion avec une fraction de pyrazine substituée et qui inhibent l'activité de l'Akt, une sérine/thréonine-protéine-kinase. L'invention concerne, de plus, des compositions chimiothérapeutiques contenant les composés de l'invention et des méthodes de traitement du cancer comprenant l'administration des composés de l'invention.

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