C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2589084
The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.
L'invention concerne des composés contenant des naphthyridines substituées inhibent l'activité de Akt, une sérine/thréonine protéine kinase. L'invention concerne en outre des compositions chimiothérapeutiques contenant les composés de l'invention, ainsi que des procédés de traitement du cancer comprenant l'administration des composés de l'invention. Ces naphthyridines substituées présentent des propriétés avantageuses inattendues, comparativement à d'autres naphthyridines spécifiées dans la publication PCT WO2003/086394, telles que des propriétés avantageuses inattendues pouvant inclure une puissance/solubilité cellulaire accrue, une plus grande sélectivité, des propriétés pharmacocinétiques améliorées, un manque d'activité hors cible, etc.
Arruda Jeannie M.
Bilodeau Mark T.
Campbell Brian T.
Cosford Nicholas D. P.
Hoffman Jacob M.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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