C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 253/06 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2522262
The present invention is directed to compounds which contain a heterocyclic triazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
La présente invention concerne des composés qui contiennent un fragment de triazine hétérocyclique qui inhibe l'activité de l'Akt, qui est une protéine sérine/thréonine kinase. Cette invention concerne en outre des compositions chimiothérapeutiques renfermant les composés de cette invention ainsi que des méthodes de traitement du cancer consistant à administrer les composés de cette invention.
Bilodeau Mark T.
Lindsley Craig W.
Zhao Zhijian
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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