Inhibitors of akt activity

Details Inhibitors of akt activity Inhibitors of akt activity

C - Chemistry, Metallurgy

07

D

C07D 471/02 (2006.01)

Patent

CA 2588474

The instant invention provides for canthine analogs that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

La présente invention concerne des analogues de la canthine qui inhibent l'activité de Akt. En particulier, les composés de l'invention inhibent sélectivement une ou plusieurs isoformes de Akt. L'invention concerne également des compositions contenant lesdits composés inhibiteurs, et des méthodes pouvant inhiber l'activité de Akt par administration du composé à un patient nécessitant un traitement contre le cancer.

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