Inhibitors of akt activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) C07D 241/42 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2480880

The present invention is directed to compounds comprising a 2,3- diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention

La présente invention concerne des composés comprenant un groupe fonctionnel 2,3-diphénylquinoxaline inhibant l'activité de Akt, une protéine kinase serine/thréonine. La présente invention concerne également des compositions chimiothérapeutiques contenant ces composés, ainsi qu des méthodes permettant de traiter le cancer, lesquelles méthodes consistent à administrer les composés susmentionnés.

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