Inhibitors of akt activity

Details Inhibitors of akt activity Inhibitors of akt activity

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/52 (2006.01) A61P 5/48 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2522430

The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

La présente invention concerne des composés qui contiennent un noyau hétérocyclique à cinq éléments fusionnés à une fraction pyridine substituée qui inhibe l'activité de Akt, une sérine/thréonine protéine kinase. L'invention concerne en outre des compositions chimiothérapeutiques renfermant les composés de l'invention et des méthodes de traitement du cancer passant par l'administration desdits composés.

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