C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4375 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 401/10 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01) C07D 473/32 (2006.01) C07D 475/04 (2006.01)
Patent
CA 2480800
The present invention is directed to compounds comprising a 2,3- diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
la présente invention concerne des composés comprenant une fraction 2,3-diphénylquinoxaline qui inhibe l'activité d'Akt, une sérine/thréonine protéine kinase. L'invention concerne également des compositions chimiothérapeutiques renfermant les composés de l'invention et des méthodes de traitement du cancer consistant en l'administration desdits composés.
Bilodeau Mark T.
Duggan Mark E.
Hartnett John C.
Lindsley Craig W.
Manley Peter J.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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