C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/00 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2561311
The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
La présente invention concerne des composés qui contiennent des fractions pyridazines et pyrimidines substituées inhibant l'activité d'Akt, une protéine kinase sérine/thréonine. L'invention concerne également des compositions chimiothérapeutiques contenant les composés susmentionnés, ainsi que des méthodes destinées à traiter le cancer et consistant à administrer lesdits composés.
Bilodeau Mark T.
Chua Peter C.
Cosford Nicholas D. P.
Hoffman Jacob M.
Nagasawa Johnny Yasuo
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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