C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2561315
The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
L'invention concerne des composés contenant des napthyridines substituées qui inhibent l'activité d'Akt, une sérine/thréonine protéine kinase. L'invention concerne, en outre, des conditions chimiothérapeutiques contenant les composés de cette invention et des procédés destinés au traitement du cancer qui consistent à administrer lesdits composés.
Bilodeau Mark T.
Chen Chixu
Cosford Nicholas D. P.
Eastman Brian W.
Hartnett John C.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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