C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/14 (2006.01) A61K 31/4375 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2597456
The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
La présente invention a trait à des composés inhibiteurs de l'activité d'Akt. En particulier, les composés de l'invention sont des inhibiteurs sélectifs d'une ou de deux isoformes d'Akt. L'invention a également trait à des compositions comportant de tels composés inhibiteurs et des procédés d'inhibition de l'activité d'Akt par l'administration du composé à un patient qui a besoin d'un traitement du cancer.
Cosford Nicholas D. P.
Layton Mark E.
Liang Jun
Lindsley Craig W.
Sanderson Philip E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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