Inhibitors of akt activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/14 (2006.01) A61K 31/4375 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2726317

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the com-pound to a patient in need of treatment of cancer.

La présente invention porte sur des composés naphtyridines substitués qui inhibent l'activité Akt. En particulier, les composés décrits inhibent sélectivement une ou deux des isoformes Akt, de préférence Akt1. L'invention porte également sur des compositions comportant de tels composés inhibiteurs et sur des procédés d'inhibition de l'activité Akt, notamment Akt1, par ladministration du composé à un patient ayant besoin d'un traitement contre le cancer.

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