C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2750051
The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
La présente invention porte sur des composés qui inhibent l'activité d'Akt. En particulier, les composés décrits inhibent de façon sélective une ou deux des isoformes d'Akt. L'invention porte également sur des compositions renfermant de tels composés inhibiteurs et sur des procédés d'inhibition de l'activité d'Akt par l'administration du composé à un patient ayant besoin d'un traitement anticancéreux.
Armstrong Donna J.
Goto Yasuhiro
Hashihayata Takashi
Kato Tetsuya
Kelly Michael J. III
Merck Sharp & Dohme Corp.
Msd K.k.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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