Inhibitors of akt/pkb with anti-tumor activity

Details Inhibitors of akt/pkb with anti-tumor activity Inhibitors of akt/pkb with anti-tumor activity

C - Chemistry, Metallurgy

07

H

C07H 19/23 (2006.01) A61K 31/7064 (2006.01) A61P 35/00 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2695330

The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other cell in which expression of an Akt protein is elevated or constitutively active, comprising contacting the cell with an effective amount of a compound of formula I. The subject invention also concerns methods for treating cancer or a tumor in a person or animal comprising administering an effective amount of a compound of formula I to the person or animal.

L'invention concerne des matériaux et des procédés permettant d'inhiber la voie AKT/PKB. Dans un mode de réalisation, un composé de l'invention inhibe l'activité de kinase et les taux de phosphorylation de protéines Akt. L'invention concerne également des procédés permettant d'inhiber ou de tuer une cellule cancéreuse ou une autre cellule dans laquelle une expression d'une protéine Akt est élevée ou constitutivement active. Les procédés comprennent la mise en contact de la cellule avec une quantité efficace d'un composé de formule I. L'invention concerne enfin des procédés de traitement du cancer ou d'une tumeur chez l'humain ou l'animal. Le procédé comporte l'administration d'une quantité efficace d'un composé de formule I à la personne ou à l'animal.

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