Inhibitors of .alpha.4.beta.1 mediated cell adhesion

Details Inhibitors of .alpha.4.beta.1 mediated cell adhesion Inhibitors of .alpha.4.beta.1 mediated cell adhesion

C - Chemistry, Metallurgy

07

D

C07D 277/06 (2006.01) A61K 31/33 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 207/26 (2006.01) C07D 207/28 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 221/00 (2006.01) C07D 223/06 (2006.01) C07D 235/00 (2006.01) C07D 263/00 (2006.01) C07D 263/06 (2006.01) C07D 277/00 (2006.01) C07D 277/60 (2006.01) C07D 279/12 (2006.01) C07D 281/06 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 41

Patent

CA 2342778

The present invention relates to compound of formula (I), that are potent inhibitors of .alpha.4.beta.1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. Specifically, the molecules of the present invention can be used for treating or preventing .alpha.4.beta.1 adhesion mediated conditions in a mammal such as a human. This method may comprise administering to a mammal or a human patient an effective amount of the compound or composition as explained in the present specification.

L'invention porte sur un composé de la formule (I) qui est un puissant inhibiteur de l'adhésion cellulaire induite par .alpha.¿4?.beta.¿1?, cette adhésion s'effectuant sur VCAM ou CS-1, et qui peut être utile dans le traitement des maladies inflammatoires. Les molécules de cette invention peuvent être notamment utilisées dans le traitement ou la prévention des états induits par l'adhésion de .alpha.¿4?.beta.¿1? chez l'homme. Ce procédé consiste à administrer à un mammifère ou à un être humain une quantité efficace du composé ou de la composition décrit dans la présente demande.

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