Inhibitors of androgen-independent activation of androgen...

Details Inhibitors of androgen-independent activation of androgen... Inhibitors of androgen-independent activation of androgen...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2302169

Androgen-independent activation of the androgen receptor is localized to the region of amino acids 234-391 of human androgen receptor protein. Peptides derived and nucleic acids encoding such peptides are provided. The peptides are useful as activation domains, as inhibitors of androgen-independent activation of androgen receptor, for screening compounds that affect androgen-independent activation of androgen receptor, and for treatment of androgen mediated diseases such as prostate cancer. Methods for screening compounds affecting androgen-independent activation of androgen receptor are also provided.

L'activation indépendante de l'androgène du récepteur d'androgène est localisée dans la région comprenant les acides aminés 234-391 de la protéine du récepteur d'androgène humain. L'invention concerne des peptides dérivés et des acides nucléiques codant pour ces peptides. Ces peptides sont utiles comme domaines d'activation, comme inhibiteurs de l'activation indépendante des androgènes du récepteur d'androgène, et comme agents thérapeutiques pour des pathologies d'origine androgénique telles que le cancer de la prostate. L'invention concerne en outre des procédés permettant la sélection de composés affectant l'activation indépendante de l'androgène du récepteur d'androgène.

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