Inhibitors of anti-apoptotic proteins

Details Inhibitors of anti-apoptotic proteins Inhibitors of anti-apoptotic proteins

C - Chemistry, Metallurgy

07

D

C07D 277/36 (2006.01) A61K 31/426 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2703723

Various compounds comprising a thiazolidine ring are described as well as the use of such compounds to inhibit at least one BCL-2 protein family member. One of the compounds described has the structure the structure A, wherein each of R1 and R2 comprises hydrogen, a substituted or unsubstituted straightchained aliphatic group, a halogen, an alkoxyl, a halogen-substituted alkyl, a halogensubstituted alkoxyl, hydroxyl, carboxyl, cyano group, an amido group, a substituted or unsubstituted cycloaliphatic group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heterocyclic group; X comprises oxygen, sulfur, or imino group; and Z comprises a moiety such as naphthaline or dehydronaphthaline, among others.

L'invention concerne divers composés comprenant un cycle thiazolidine ainsi que l'utilisation de tels composés pour inhiber au moins un membre de la famille des protéines BCL-2. L'un des composés décrits possède la structure A dans laquelle chacun de R1 et R2 comprend un atome d'hydrogène, un groupe aliphatique à chaîne droite substitué ou non substitué, un halogène, un alcoxyle, un alkyle substitué par halogène, un alcoxyle substitué par halogène, un hydroxyle, un carboxyle, un groupe cyano, un groupe amido, un groupe cycloaliphatique substitué ou non substitué, un groupe aromatique substitué ou non substitué ou un groupe hétérocyclique substitué ou non substitué ; X comprend un oxygène, un soufre ou un groupe imino ; et Z comprend une fraction telle que de la naphtaline ou de la déshydronaphtaline, entre autres.

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