Inhibitors of apoptosis

Details Inhibitors of apoptosis Inhibitors of apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01H 5/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/82 (2006.01) C12Q 1/68 (2006.01) G01N 33/533 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2399769

The present invention is generally directed to Inhibitor of Apoptosis Proteins ("IAPs"), nucleic acid molecules encoding IAPs, viral vectors, recombinant baculoviruses comprising an IAP, transgenic plants comprising an IAP nucleic acid, and methods of assaying for compounds which bind to an IAP. In general, the IAP nucleic acids of the invention have 85 % or higher identity to SEQ ID NO:1 and the IAP of the invention have 90 % or higher identity to SEQ ID NO:3.

La présente invention se rapporte de manière générale à des protéines inhibitrices de l'apoptose (IAP), à des molécules d'acides nucléiques codant ces protéines IAP, à des vecteurs viraux, à des baculovirus de recombinaison comportant une protéine IAP, à des plantes transgéniques comportant un acide nucléique d'IAP et à des méthodes de détection de composés qui se lient à une IAP. De manière générale, les acides nucléiques de ces protéines IAP sont identiques à SEQ ID NO:1 à au moins 85 % et la protéine IAP de cette invention est identique à SEQ ID NO:3 à au moins 90 %.

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