A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/36 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/381 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/4184 (2006.01) A61K 31/4245 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) A61K 31/4409 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2757574
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
L'invention porte sur des composés organiques présentant la capacité d'inhiber une sécrétion de toxine effectrice ou une translocation à médiation par les systèmes de sécrétion de type III bactériens. Les composés inhibiteurs du système de sécrétion de type III décrits sont utiles pour combattre des infections par des bactéries Gram négatives telles que Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., Escherichia coli enteropathogène et enteroinvasive, et Chlamydia spp. ayant de tels systèmes de sécrétion de type III.
Aiello Daniel
Moir Donald T.
Peet Norton P.
Williams John D.
Microbiotix Inc.
Smart & Biggar
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