Inhibitors of beta amyloid production

Details Inhibitors of beta amyloid production Inhibitors of beta amyloid production

C - Chemistry, Metallurgy

07

C

C07C 311/17 (2006.01) A61K 31/18 (2006.01) A61K 31/381 (2006.01) A61P 25/28 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2693959

Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R4-R3 are defined herein. Also provided are pharmaceutical compositions containing these compounds and/or prodrugs of these compounds and a physiologically compatible carrier. These compounds are specifically useful for inhibiting beta amyloid production, and treating Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome.

L'invention concerne de nouveaux composés sulfonamide utiles dans le traitement d'affections liées à la production de bêta amyloïde, ainsi que des voies pour leur préparation. Les composés sulfonamide ont la structure suivante, dans laquelle R4 et R3 sont définis ici. Sont également proposés des compositions pharmaceutiques contenant ces composés et/ou des promédicaments de ces composés et un support physiologiquement compatible. Ces composés sont spécialement utiles pour inhiber la production de bêta amyloïde et traiter la maladie d'Alzheimer, une angiopathie d'amyloïde, une angiopathie amyloïde cérébrale, une amyloïdose systémique, une hémorragie cérébrale héréditaire avec amyloïdose du type Dutch, y compris myosite corporelle, trouble cognitif léger (MCI) et syndrome de Down.

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