Inhibitors of bruton's tyrosine kinase

Details Inhibitors of bruton's tyrosine kinase Inhibitors of bruton's tyrosine kinase

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/4412 (2006.01) A61K 31/444 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2753341

This application discloses compounds according to general Formula (A) wherein, variable Z* is defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula (A) and at least one carrier, diluent or excipient.

Cette invention porte sur des composés qui inhibent la Btk et qui sont représentés par la formule générale (A), dans laquelle la variable Z* est telle que définie dans la description. Les composés de la présente invention sont utiles pour moduler l'activité de la Btk et pour traiter des maladies associées à une activité excessive de la Btk. Les composés sont en outre utiles pour traiter des maladies inflammatoires et auto-immunes associées à une prolifération aberrante de lymphocytes B telles que la polyarthrite rhumatoïde. L'invention porte également sur des compositions contenant les composés de la formule (A) et au moins un véhicule, diluant ou excipient.

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