Inhibitors of bruton's tyrosine kinase

Details Inhibitors of bruton's tyrosine kinase Inhibitors of bruton's tyrosine kinase

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2681756

Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.

La présente invention concerne des composés inhibiteurs de kinase irréversibles, des procédés de synthèse de ces inhibiteurs irréversibles, et des procédés pour les utiliser dans le traitement de maladies. L'invention décrit, en outre, des procédés, des dosages et des systèmes permettant de déterminer un inhibiteur irréversible de protéine approprié, comprenant une kinase.

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