C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A01N 43/90 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 487/04 (2006.01) C12N 9/99 (2006.01)
Patent
CA 2663116
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
La présente invention concerne des composés qui forment des liaisons covalentes avec la tyrosine kinase de Bruton (Btk). Cette invention concerne également des inhibiteurs irréversibles de la tyrosine kinase de Bruton (Btk). Cette invention concerne en outre des méthodes de préparation de ces composés, des compositions pharmaceutiques contenant ces composés, ainsi que des méthodes d'utilisation de ces inhibiteurs de la tyrosine kinase de Bruton (Btk), seuls ou combinés à d'autres agents thérapeutiques, pour traiter des maladies ou affections auto-immunes, des maladies ou affections hétéro-immunes, un cancer tel qu'un lymphome, et des maladies ou affections inflammatoires.
Honigberg Lee
Pan Zhengying
Verner Erik
Pharmacyclics Inc.
Smart & Biggar
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