Inhibitors of c-amp phosphodiesterase and tnf

Details Inhibitors of c-amp phosphodiesterase and tnf Inhibitors of c-amp phosphodiesterase and tnf

C - Chemistry, Metallurgy

07

D

C07D 213/72 (2006.01) A61K 31/00 (2006.01) C07C 43/225 (2006.01) C07C 43/247 (2006.01) C07C 45/00 (2006.01) C07C 45/29 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 49/84 (2006.01) C07C 59/58 (2006.01) C07C 59/60 (2006.01) C07C 59/62 (2006.01) C07C 65/21 (2006.01) C07C 65/24 (2006.01) C07C 65/42 (2006.01) C07C 69/76 (2006.01) C07C 69/92 (2006.01) C07C 69/94 (2006.01) C07C 205/59 (2006.01) C07C 217/58 (2006.01) C07C 217/88 (2006.01) C07C 233/75 (2006.01) C07C 235/56 (2006.01) C07C 255/60 (2006.01

Patent

CA 2140441

This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase. Compounds according to the invention are of formula I which has the following general chemical structure:

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