Inhibitors of c-fms kinase

Details Inhibitors of c-fms kinase Inhibitors of c-fms kinase

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 35/00 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2649924

The invention is directed to compounds of Formula (I): Formula (I), wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.

L'invention porte sur des composés de formule (I) dans laquelle Z, X, J, R2 et W sont tels que définis dans la description, ainsi que sur des solvates, des hydrates, des tautomères et des sels de ceux-ci acceptables d'un point de vue pharmaceutique qui inhibent des protéines tyrosine kinases, notamment la c-fms kinase. L'invention porte également sur des méthodes de traitement de maladies auto-immunes, et de maladies ayant une composante inflammatoire; sur des méthodes de traitement de la métastase du cancer des ovaires, du cancer utérin, du cancer du sein, du cancer du côlon, du cancer de l'estomac, de la leucémie à tricholeucocytes, de l'épithélioma du poumon à grandes cellules; et de traitement de la douleur, y compris la douleur osseuse provoquée par la métastase tumorale ou l'ostéoarthrite ou la douleur viscérale, inflammatoire et neurogénique. Ces méthodes permettent de traiter également l'ostéoporose, la maladie de Paget et d'autres maladies dans lesquelles la résorption osseuse induit une morbidité, telles que l'arthrite, la défaillance de prothèse, l'ostéosarcome, le myélome et la métastase tumorale sur l'os, ces méthodes utilisant les composés de formule (I) de l'invention.

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