C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/341 (2006.01) A61K 31/4155 (2006.01) A61K 31/4192 (2006.01) A61K 31/42 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2381882
The present invention provides compounds of formula (I) where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
L'invention concerne des composés de formule (I) dans laquelle R<1> représente H, CONH2, T(n)-R, ou T(n)-Ar<2>, n peut valoir zéro ou un, et G, XYZ, et Q sont tels que décrits ci-dessous. Lesdits composés sont des inhibiteurs de la protéine kinase, notamment des inhibiteurs de JNK, protéine kinase de mammifère impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse à des stimuli extracellulaires. L'invention porte également sur des procédés de production desdits inhibiteurs, sur des compositions pharmaceutiques comprenant les inhibiteurs de l'invention ainsi que sur des procédés d'utilisation desdites compositions dans le traitement ou la prévention de divers troubles.
Baker Christopher
Bemis Guy
Cao Jingrong
Gao Huai
Green Jeremy
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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