C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2491895
The present invention provides compounds of formula I: (I) or a pharmaceutically acceptable derivative thereof, wherein R1, R2, A, G, and W are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, Lck, Src, and Aurora kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des composés représentés par la formule (I) ou un dérivé pharmaceutiquement acceptable de ces derniers; les R?1¿, R?2¿, A, G et W de la formule étant tels que décrits dans le descriptif. Ces composés sont des inhibiteurs des protéines kinases, plus particulièrement de JNK qui est une protéine kinase de mammifère impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse cellulaire aux stimuli extracellulaires, et des kinases Lck, Src et Aurora. Cette invention se rapporte également à des méthodes de production de ces inhibiteurs, à des compositions pharmaceutiques comprenant les inhibiteurs selon l'invention et à des méthodes d'utilisation desdites compositions dans le traitement et la prévention de divers troubles.
Ledeboer Mark
Moon Young Choon
Wang Jian
Robic
Vertex Pharmaceuticals Incorporated
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