C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/02 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 409/00 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2443487
The present invention provides compounds of formula (I): or a pharmaceutically acceptable derivative thereof, wherein A, B, Ra, R1, R2, R3 and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des composés de formule (I) : ou un dérivé pharmaceutiquement acceptable, où A, B, R?a¿, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que décrits dans la spécification. Lesdits composés sont des inhibiteurs de protéine kinase, en particulier des inhibiteurs de JNK, une protéine kinase de mammifère impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse à des stimuli extracellulaires ; de Lck et Src kinase. L'invention concerne également des méthodes de production desdits inhibiteurs. L'invention concerne également des compositions pharmaceutiques comprenant les inhibiteurs selon l'invention et des méthodes d'utilisation desdites compositions dans le traitement et la prévention de divers troubles.
Cao Jingrong
Gao Huai
Green Jeremy
Harrington Edmund
Ledeboer Mark
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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