C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 38/57 (2006.01) C07D 213/54 (2006.01) C07D 213/73 (2006.01)
Patent
CA 2371213
The present invention relates to compounds of Formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases associated with carboxypeptidase U. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.
La présente invention concerne des composés de la formule (I), et leurs sels ou solvates pharmaceutiquement acceptables, ou les solvates de tels sels. Ces composés inhibent la carboxypeptidase U et peuvent donc servir à la prévention et au traitement de maladies associées à la carboxypeptidase U. L'invention concerne également les composés de l'invention destinés à être utilisés en thérapie; des procédés de préparation de tels composés; des compositions pharmaceutiques contenant au moins un composé de l'invention, ou un sel ou un solvate pharmaceutiquement acceptable de ce dernier, comme composant actif; et l'utilisation des composés actifs dans la production de médicaments destinés à l'utilisation médicale susmentionnée.
Linschoten Marcel
Polla Magnus
Svensson Peder
Astrazeneca Ab
Fetherstonhaugh & Co.
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