Inhibitors of cathepsin s

Details Inhibitors of cathepsin s Inhibitors of cathepsin s

C - Chemistry, Metallurgy

07

D

C07D 307/32 (2006.01) A61K 31/341 (2006.01) A61K 31/5377 (2006.01) C07D 307/68 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2542963

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

L'invention concerne des composés, des compositions et des méthodes pour l'inhibition sélective de la cathépsine S. Dans un aspect préféré de l'invention, la cathépsine S est sélectivement inhibée en présence d'au moins un autre isozyme de cathépsine. L'invention concerne également des méthodes de traitement d'un état pathologique chez un sujet, consistant à inhiber sélectivement la cathépsine S.

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