Inhibitors of cathepsin s

Details Inhibitors of cathepsin s Inhibitors of cathepsin s

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) C07D 231/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2534489

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

La présente invention concerne des composés, des compositions et des méthodes d'inhibition sélective de la cathepsine S. Dans un aspect préféré, la cathepsine S est sélectivement inhibée en présence d'au moins une autre isoenzyme de cathepsine. Cette invention a aussi trait à des méthodes de traitement d'un état d'une maladie chez un sujet par inhibition sélective de la cathepsine S.

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