Inhibitors of cathepsin s

Details Inhibitors of cathepsin s Inhibitors of cathepsin s

C - Chemistry, Metallurgy

07

D

C07D 209/04 (2006.01) A61K 31/404 (2006.01) A61K 31/423 (2006.01) A61K 31/454 (2006.01) A61K 31/5375 (2006.01) C07D 265/30 (2006.01) C07D 295/13 (2006.01) C07D 411/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2535930

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

L'invention concerne des composés, des compositions et des procédés d'inhibition sélective de la cathepsine S. Selon un aspect préféré, la cathepsine S est sélectivement inhibée en présence d'au moins une autre iso-enzyme de cathepsine. L'invention concerne également des procédés de traitement d'un état pathologique chez un sujet par inhibition sélective de la cathepsine S.

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