Inhibitors of ccr9 activity

Details Inhibitors of ccr9 activity Inhibitors of ccr9 activity

C - Chemistry, Metallurgy

07

C

C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 1/00 (2006.01) C07C 311/29 (2006.01)

Patent

CA 2631436

Compounds of formula (I), in which R1 and R2 are independently a substituted phenyl group, where the substituents are as defined in the claims and with the proviso that at least one of the substituents is a cyano, carboxy or (C1- 4)alkoxycarbonyl group, are inhibitors of CCR9 activity useful for therapeutic treatment, particularly of irritable bowel disease.

La présente invention concerne des composés de formule (I) dans laquelle R1 et R2 représentent indépendamment un groupe phényle substitué. Les substituants sont tels que définis dans les revendications de la présente invention, sous réserve qu'au moins un des substituants soit un groupe cyano, carboxy ou (C1-4)alkoxycarbonyle. Ces composés constituent des inhibiteurs de l'activité du récepteur CCR9 utilisés dans le cadre d'une thérapie, en particulier pour traiter le syndrome du côlon irritable.

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